San Francisco:
Toronado, great beer bar
Anchor Brewing, SF original and great tour and tastings
City Beer, the best selection of beers for tasting in the City
Mikkeller Bar, if you don't know Mikkeller beers, you should try this
For beer and food:
The Monks Kettle, you want to go here, food made for and with beer
Suppenkuche, German biergarten done Cali style.
The Fat Angel, great and rare beer selection and great food
Food:
Thousands of options...my favorites within a reasonable budget...
Mission Chinese, bad locale, great Chinese American food
Mission Bowling, great fried chicken and everything else
U.S. Restaurant, old S.F. style Italian-American pasta house
Original Joe's North Beach, S.F. institution
Every single food vendor at the Ferry Plaza, Gott's is a favorite, as is Hog Island Oysters
Super Duper Burgers, best burgers in S.F.
Ton Kiang, good dim sum cheap
Yank Sing, once the best place in S.F. for dim sum, not cheap
Shanghai Dumpling King, soup dumplings
Old Mandarin Islamic Chinese food, one of the best and most unique Chinese places in the country
Ike's Place, sandwiches galore
Tony's Pizza Napoletano, one of the best pizzas in the country
I got tons more here as well